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1H-Purine-2,6-dione
CAS No. 2253744-57-7
1H-Purine-2,6-dione ( ——— )
产品货号. M39452 CAS No. 2253744-57-7
TH5427 hydrochloride 是一种有效的选择性 NUDT5 抑制剂 (IC50=29 nM)。TH5427 hydrochloride 对 NUDT5 的选择性比 MTH1 高 690 倍。TH5427 hydrochloride 阻断乳腺癌细胞孕激素依赖性、PAR 衍生的核 ATP 合成及随后的染色质重塑、基因调控和增殖。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥4589 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称1H-Purine-2,6-dione
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TH5427 hydrochloride 是一种有效的选择性 NUDT5 抑制剂 (IC50=29 nM)。TH5427 hydrochloride 对 NUDT5 的选择性比 MTH1 高 690 倍。TH5427 hydrochloride 阻断乳腺癌细胞孕激素依赖性、PAR 衍生的核 ATP 合成及随后的染色质重塑、基因调控和增殖。
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产品描述TH5427 hydrochloride is a potent, selective NUDT5 inhibitor (IC50=29 nM). TH5427 hydrochloride shows an apparent 690-fold selectivity for NUDT5 over MTH1. TH5427 hydrochloride blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells.
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体外实验———
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体内实验TH5427 hydrochloride inhibits progestin-dependent nuclear ATP synthesis in breast cancer cells. TH5427 hydrochloride significantly disrupted EGFR and MMTV-luc expression following progestin stimulation. TH5427 hydrochloride abrogates the progestin-dependent proliferation response in T47DWT cells.
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同义词———
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通路Others
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靶点Other Targets
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受体———
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研究领域———
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适应症———
化学信息
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CAS Number2253744-57-7
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分子量527.79
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分子式C20H21Cl3N8O3
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纯度>98% (HPLC)
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溶解度———
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SMILES———
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化学全称———
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Page BDG, et al. Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells published correction appears in Nat Commun. 2019 Nov 1;10(1):5050. Nat Commun. 2018;9(1):250. Published 2018 Jan 17.?
产品手册
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