MU 380

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MU380 是一种强效的、选择性?CHK1 抑制剂，可以诱导细胞凋亡 (apoptosis)，具有抗癌活性。

MU380 is a potent and selective CHK1 inhibitor that induces apoptosis and has anticancer activity.

MU380 (20 mg/kg, 使用20% aqueous Kolliphor 溶液, 从第 14天 到第 28 天，每 3 天使用一次) 可以有效抑制小鼠肿瘤的生长。Animal Model:NOD-scid?IL2Rγnull?mice Dosage:20 mg/kg Administration:In 20% aqueous Kolliphor solution, every three days from day 14 to day 28 Result:Significantly inhibit the growth of tumors and gradually reduce their volume, with an average reduction of about 61%.

MU380 (100 nM, 24 h) 有效抑制 CHK1 激酶并使淋巴肿瘤细胞对吉西他滨敏感。 MU380 (400 nM, 24 h) 可以显着影响细胞周期概况，诱导分裂和非分裂原发性慢性淋巴细胞白血病淋巴细胞死亡。Apoptosis Analysis Cell Line:MEC-1and MEC-2?cells Concentration:400 nM Incubation Time:24 h Result:Showed accumulation in S phase as well as reduction in G2/M phase, greatly reduced rate of DNA synthesis, and marked induction of apoptosis (PARP protein cleavage).Western Blot Analysis Cell Line:Chronic lymphocytic leukemia cells Concentration:100 nM or 200 nM Incubation Time:24 h Result:Potently blocked CHK1 activation while enhancing ATR kinase signaling to CHK1 (pS317 and pS345), and resulted in decreased levels of total CDC25A and CDC25C, pY15 CDK1, cyclin B1 and cyclin E1.

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Others

Other Targets

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2109805-78-7

430.23

C15H15BrF3N7

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years