Nigranoic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nigranoic acid 是五味子中分离得到的一种三萜类化合物。Nigranoic acid 能抑制 HIV-1 逆转录酶。在脑缺血再灌注动物模型中，Nigranoic acid 通过 PARP/AIF 信号通路保护大脑。

Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model.

Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation. Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.Animal Model:Sprague–Dawley rats (200-300 g), ischemia–reperfusion model Dosage:1 mg/kg Administration:Intragastric; 6 hours and 2 hours before brain ischemia Result:Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.

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黑五味子酸

Others

Other Targets

HIV-1 reverse transcriptase

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39111-07-4

470.68

C30H46O4

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years