Eugeniin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tellimagrandin II (Eugeniin)，是 4C1-葡萄糖衍生的鞣花丹宁系列的第一个中间体，也抑制Staphylococcus aureus的耐药性。

Tellimagrandin II (Eugeniin), with oral activity, is the first intermediate of the ellagitannin series derived from 4C1-glucose. It inhibits the resistance of Staphylococcus aureus by disrupting the integrity of the cell wall, leading to the loss of cytoplasmic contents. Additionally, Tellimagrandin II exhibits anti-inflammatory effects and inhibits acetylcholinesterase (AChE) activity, improving memory impairment. Tellimagrandin II holds potential for research in the fields of antibacterial, anti-inflammatory, and neurodegenerative diseases.

Tellimagrandin II (100 和 200 mg/kg，口服，每日一次，共 10 天) 改善了 Scopolamine 诱导的健忘 ICR 小鼠的学习和记忆功能。Animal Model:Scopolamine -induced amnesiac ICR mouse model Dosage:100 and 200 mg/kg Administration:Oral gavage (p.o.), once daily for 10 days Result:Improved learning and memory functions in the passive avoidance and water maze tests.

Tellimagrandin II (40 μg/mL, 24 小时) 破坏了 Staphylococcus aureus 的细胞壁完整性。Tellimagrandin II (40 μg/mL, 5 小时) 显著抑制了甲氧西林耐药性 Staphylococcus aureus 中 mecA mRNA 和 PBP2a 蛋白的表达。Tellimagrandin II (50 μM, 6 小时) 显著抑制了 RAW264.7 细胞中 LPS 诱导的 NO 生成以及 NOS2 mRNA 和蛋白的表达。Tellimagrandin II (25 或 50 μM, 12 小时) 显著抑制了 RAW264.7 细胞中 LPS诱导的 COX-2 蛋白水平和 PGE2 的生成。Tellimagrandin II (12.5-50 μM, 10 分钟) 表现出显著的乙酰胆碱酯酶 (AChE) 抑制活性，其 IC50 为 18.6 μM。Western Blot Analysis Cell Line:Methicillin-Resistant Staphylococcus aureus Concentration:40 μg/mL Incubation Time:5 h Result:Significantly reduced PBP2a protein levels.Real Time qPCR Cell Line:Methicillin-Resistant Staphylococcus aureus Concentration: 40 μg/mL Incubation Time:5 h Result:Significantly reduced mecA mRNA expression.Real Time qPCR Cell Line:LPS -induced inflammation RAW264.7 cells (murine macrophages) Concentration:50 μM Incubation Time:6 h Result: Significantly reduced NOS2 gene expression levels induced by LPS .Western Blot Analysis Cell Line:LPS-induced inflammation RAW264.7 cells (murine macrophages) Concentration:25 和 50 μM Incubation Time:12 h Result:Significantly reduced LPS -induced COX-2 protein levels and PGE2 production.

特里马素II

Others

Other Targets

———

———

———

81571-72-4

938.665

C41H30O26

>98% (HPLC)

DMSO : 100 mg/mL (106.53 mM; ultraphonic; )

———

———

(-20℃)

With Ice Pack

≥ 2 years