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首页- Products - Others - Other Targets - Dehydrocurdione

Dehydrocurdione

CAS No. 38230-32-9

Dehydrocurdione ( 去氢莪术二酮 )

产品货号. M38871 CAS No. 38230-32-9

Dehydrocurdione，一种 zedoary 衍生的倍半萜，在 RAW 264.7 巨噬细胞中诱导血红素加氧酶 (HO)-1，一种抗氧化酶。Dehydrocurdione 与 Keap1 相互作用，导致 Nrf2 易位，随后激活 HO-1 E2 增强子。Dehydrocurdione 抑制脂多糖诱导的 NO 释放，NO 是炎症的标志物。抗炎活性。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ￥2233 有现货
500MG 获取报价 有现货
1G 获取报价 有现货
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生物学信息

  • 产品名称
    Dehydrocurdione
  • 注意事项
    本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
  • 产品简述
    Dehydrocurdione，一种 zedoary 衍生的倍半萜，在 RAW 264.7 巨噬细胞中诱导血红素加氧酶 (HO)-1，一种抗氧化酶。Dehydrocurdione 与 Keap1 相互作用，导致 Nrf2 易位，随后激活 HO-1 E2 增强子。Dehydrocurdione 抑制脂多糖诱导的 NO 释放，NO 是炎症的标志物。抗炎活性。
  • 产品描述
    Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidative enzyme, in RAW 264.7 macrophages. Dehydrocurdione interacts with Keap1, resulting in Nrf2 translocation followed by activation of the HO-1 E2 enhancer. Dehydrocurdione suppresses lipopolysaccharide-induced NO release, a marker of inflammation. Anti-inflammatory activity.
  • 体外实验
    Dehydrocurdione (P.o ;120 mg/kg, daily for 12 days) significantly reduces chronic adjuvant arthritis.Dehydrocurdione (200 mg/kg; p.o.; Sprague-Dawley rats) dose-dependently inhibits carrageenan-induced paw edema.Animal Model:Wistar rats Dosage:120 mg/kg Administration:P.o ; daily for 12 days Result:Significantly reduces chronic adjuvant arthritis.
  • 体内实验
    Dehydrocurdione (RAW 264.7 cells) concentration-dependently increases the HO-1 mRNA level for 3 hr and the protein level for 6 hr, and both effects reached significance at a concentration of 100 μM. Dehydrocurdione interacts with Keap, resulting in Nrf2 translocation followed by activation ofthe HO-1 E2 enhancer.Western Blot Analysis Cell Line:RAW 264.7 cells Concentration:100 μM Incubation Time:24 hours Result:Transiently increased the HO-1 protein level, and its effect peaked at 3-6 hr.
  • 同义词
    去氢莪术二酮
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    ———
  • 研究领域
    ———
  • 适应症
    ———

化学信息

  • CAS Number
    38230-32-9
  • 分子量
    234.33
  • 分子式
    C15H22O2
  • 纯度
    >98% (HPLC)
  • 溶解度
    ———
  • SMILES
    ———
  • 化学全称
    ———

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1. Ohnishi M, et al. Curcuma sp.-derived dehydrocurdione induces heme oxygenase-1 through a Michael reaction between its α, β-unsaturated carbonyl and Keap1. Phytother Res. 2018;32(5):892-897.?2. Yoshioka T, et al. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflamm Res. 1998;47(12):476-481.?
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