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Licarin A b
CAS No. 51020-86-1
Licarin A b ( 里卡灵A )
产品货号. M38735 CAS No. 51020-86-1
Licarin A ((+)-Licarin A) 显着降低二硝基苯肼-人血清白蛋白 (DNP-HSA) 刺激的 RBL-2H3 细胞。具有抗过敏作用。Licarin A 降低 TNF-α 和 PGD2 产生，和 COX-2 表达。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1131 | 有现货 |
|
| 10MG | ￥1696 | 有现货 |
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| 25MG | ￥3088 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Licarin A b
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Licarin A ((+)-Licarin A) 显着降低二硝基苯肼-人血清白蛋白 (DNP-HSA) 刺激的 RBL-2H3 细胞。具有抗过敏作用。Licarin A 降低 TNF-α 和 PGD2 产生，和 COX-2 表达。
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产品描述Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC50=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression.
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体外实验———
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体内实验Licarin A is found in plants such asAristolochia taliscana, Machilus thunbergii and Myristica fragrans, which are used as spices and in folk medicines for nervous and digestive disorders. Licarin A also exhibits anti-inflammatory effects. Licarin A (5-20 μM) reduces TNF-α and prostaglandin D2 (PGD2) secretion via the inhibition of PKCα/βII and p38 MAPK pathways. Licarin A treatment tends to reduce phosphorylated PKCα/βII and p38 MAPK protein levels.
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同义词里卡灵A
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通路Others
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靶点Other Targets
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受体———
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研究领域———
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适应症———
化学信息
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CAS Number51020-86-1
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分子量326.39
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分子式C20H22O4
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纯度>98% (HPLC)
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溶解度DMSO : ≥ 50 mg/mL (153.19 mM; ) H2O : < 0.1 mg/mL (insoluble)
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SMILESO(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1
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化学全称O(C)C1=C2C([C@@H](C)[C@@H](O2)C3=CC(OC)=C(O)C=C3)=CC(/C=C/C)=C1
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Takuya Matsui, et al. Licarin A Is a Candidate Compound for the Treatment of Immediate Hypersensitivity via Inhibition of Rat Mast Cell Line RBL-2H3 Cells. J Pharm Pharmacol. 2015 Dec;67(12):1723-32.?
产品手册
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