Acetyl Dopamine DimerIII

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-Acetyldopamine dimer-2 (compound 2) 是具有抗氧化和抗炎活性的 N-acetyldopamine 二聚体可以从蝉皮的黄色粉末中分离出来。N-Acetyldopamine dimer-2 抑制氧化低密度脂蛋白 (LDL) 氧化、ROS 生成、NO 生成和 NF-κB 活性。

N-Acetyldopamine dimer-2 (compound 2) is a N-acetyldopamine dimer that can be isolated from the yellow powder form Periostracum Cicadae with antioxidant and anti-inflammatory activities. N-Acetyldopamine dimer-2 inhibits oxidized low-density lipoprotein (LDL) oxidation, ROS generation, NO production, and NF-κB activity.

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N-Acetyldopamine dimer-2 inhibits copper-mediated, 2,2’azobis(2-amidinopropane) hydrochloride (AAPH)-mediated, and 3-morpholinosydnonimine (SIN)-1-mediated LDL oxidation with IC50 values of 1.5, 2.7 and 1.6 μM, respectively. N-Acetyldopamine dimer-2 (100 μM; 40 min) shows strong radical scavenging capacity.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently reduces the ROS level in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) dose-dependently and slightly decreases the NO production and iNOS protein expression in LPS-stimulated RAW264.7 cells.N-Acetyldopamine dimer-2 (0-400 μM; 2 h) decreases the mRNA levels of IL-6, TNF-α, and COX-2 and dose-dependently inhibits secretion of IL-6, and inhibits the LPS-induced NF-κB activation in RAW264.7 cells.Western Blot Analysis Cell Line:LPS-stimulated RAW264.7 cell line Concentration:200 and 400 μM Incubation Time:2 hours Result:Slightly decreased iNOS protein expression in LPS-stimulated RAW264.7 cells.

乙酰多巴胺二聚体III

Others

Other Targets

IC50: 1.5 μM (copper-mediated LDL oxidation), 2.7 μM (AAPH-mediated LDL oxidation), 1.6 μM (SIN-1-mediated LDL oxidation)

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916888-49-8

384.38

C20H20N2O6

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years