Epimedokoreanin B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Epimedokoreanin B 是一种天然黄酮类化合物，具有抗癌、抗炎和抗菌作用。Epimedokoreanin B 通过内质网应激介导的伴随自噬体积聚的细胞凋亡 (apoptosis) 抑制肺癌细胞的生长。Epimedokoreanin B 是一种抗牙周炎剂，可抑制牙龈蛋白酶和牙龈卟啉单胞菌的生长和生物膜形成。

Epimedokoreanin B is a natural flavonoid with anticancer, anti-inflammatory and antibacterial effects. Epimedokoreanin B inhibits the growth of lung cancer cells through endoplasmic reticulum stress-mediated apoptosis accompanied by autophagosome accumulation. Epimedokoreanin B is an anti-periodontitis agent that inhibits gingipains and Porphyromonas gingivalis growth and biofilm formation.

Cell Cytotoxicity AssayCell Line:A549, Calu1 and H1299 cells Concentration:3.13 μM, 6.25 μM, 12.5 μM and 25.0 μM Incubation Time:48 hours Result:Showed significate inhibitory effect on proliferation against lung cancer cell A549, Calu1 and H1299.Western Blot Analysis Cell Line:Human monocyte-derived macrophages (HMDMs) Concentration:5 μM Incubation Time:24 hoursResult: Significantly suppressed IL-10-induced JAK1/STAT3 activation.and H1299.

Animal Model:Female C3H mice (8-10 weeks old) injected with LM8 cells Dosage:20 mg/kg Administration:Oral administration; thrice a week; for 17 days Result:Inhibited tumor growth.

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Apoptosis

Apoptosis

Apoptosis | Antibacterial

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161068-53-7

422.47

C25H26O6

>98% (HPLC)

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C(C=C(C)C)C1=C2C(C(=O)C=C(O2)C3=CC(CC=C(C)C)=C(O)C(O)=C3)=C(O)C=C1O

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(-20℃)

With Ice Pack

≥ 2 years