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Divarasib
CAS No. 2417987-45-0
Divarasib ( —— )
产品货号. M37705 CAS No. 2417987-45-0
Divarasib (GDC-6036) 是一种具有口服生物利用度，选择性的 KRAS G12C 抑制剂，IC50 为 <0.01 μM。Divarasib 与 KRAS G12C 的开关 II (SW-II) 口袋共价结合，并将其不可逆地锁定在非活动的 GDP 结合状态。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥5596 | 有现货 |
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| 10MG | ￥7762 | 有现货 |
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| 25MG | ￥11067 | 有现货 |
|
| 50MG | ￥15159 | 有现货 |
|
| 100MG | ￥19620 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Divarasib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Divarasib (GDC-6036) 是一种具有口服生物利用度，选择性的 KRAS G12C 抑制剂，IC50 为 <0.01 μM。Divarasib 与 KRAS G12C 的开关 II (SW-II) 口袋共价结合，并将其不可逆地锁定在非活动的 GDP 结合状态。
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产品描述Divarasib (GDC-6036) is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.
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体外实验——
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体内实验Animal Model:Female C.B-17 SCID (Inbred) mice (20-21 weeks old; 24.1 g) with human NSCLC NCI-H2030.X1.1 cellsDosage:10, 25, or 100 mg/kg Administration:Oral gavage (PO) every day (QD) for 7 days (vehicle: 0.5% methylcellulose)Result:Decreased the ratio of free KRAS G12C to internal standard. Dose-dependent target engagement was observed for all time points (2, 8, and 24 h post-last dose), with over 90% KRAS G12C engagement observed for the highest dose 100 mg/kg assessed.
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同义词——
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通路Others
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靶点Other Targets
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受体Kras
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研究领域——
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适应症——
化学信息
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CAS Number2417987-45-0
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分子量622.06
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分子式C29H32ClF4N7O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (160.76 mM; 超声助溶 )
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SMILESC[C@H]1CN(CCN1c1nc(OC[C@@H]2CCCN2C)nc2c(F)c(c(Cl)cc12)-c1nc(N)cc(C)c1C(F)(F)F)C(=O)C=C
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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