VU533 ( —— )

产品货号. M36992 CAS No. 923417-09-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

VU533
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NAPE-PLD activator (VU533) 是一种强效的NAPE-PLD 激活剂，其 EC50 值为0.30 μM。NAPE-PLD activator (VU533) 可以提高 NAPE-PLD 活性，增加巨噬细胞的胞葬作用，可用于心脏代谢疾病的研究。
产品描述

APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC50 value of 0.30 μM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research.
体外实验

Cell Cytotoxicity Assay Cell Line:RAW264.7, HepG2 Concentration:0.1-30 μM Incubation Time:24 h Result:Showed no cytotoxicity when tested at 30 μM in either RAW264.7 or HepG2 cells.Cell Autophagy Assay Cell Line:BMDM Concentration:10 μM Incubation Time:6 h Result:Enhanced efferocytosis compared to vehicle treated BMDM at 10μM.
体内实验

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同义词

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通路

Metabolic Enzyme/Protease
靶点

Phospholipase
受体

Phospholipase
研究领域

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适应症

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1. Zarrow JE, et al. Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages. ACS Chem Biol. 2023 Aug 18;18(8):1891-1904.?

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