JC2-11

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JC2-11 是一种炎症小体抑制剂。JC2-11 抑制含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。JC2-11 通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。

JC2-11 is an inhibitor ofinflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1.

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Animal Model:C57BL/6 mice (8 weeks, female).Dosage:250 μg/mouse.Administration:Intraperitoneal injection; single dose.Result:Exhibited inhibitory effect on NC inflammatory body.

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Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase | IL Receptor | AIM2 | ROS | NOD-like Receptor (NLR) | Caspase

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937820-89-8

302.3

C17H15FO4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (330.80 mM )

C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2

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(-20℃)

With Ice Pack

≥ 2 years