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TRPA1-IN-2
CAS No. 2415206-22-1
TRPA1-IN-2 ( —— )
产品货号. M36925 CAS No. 2415206-22-1
TRPA1-IN-2 (compound 1) 是一种有效的口服活性 TRPA1 抑制剂，IC50 值为 0.04 μM。TRPA1-IN-2 显示出抗炎活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
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| 10MG | ￥1796 | 有现货 |
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| 25MG | ￥2716 | 有现货 |
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| 50MG | ￥3674 | 有现货 |
|
| 100MG | ￥4797 | 有现货 |
|
| 200MG | ￥6363 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1169 | 有现货 |
|
生物学信息
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产品名称TRPA1-IN-2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TRPA1-IN-2 (compound 1) 是一种有效的口服活性 TRPA1 抑制剂，IC50 值为 0.04 μM。TRPA1-IN-2 显示出抗炎活性。
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产品描述TRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.
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体外实验——
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体内实验Animal Model:16-18 g, female BABL/c mice Dosage:90 mg/kg Administration:I.p.; for 7 days Result:Reduced the total number of white blood cells and eosinophils in BALF.Animal Model:160-180 g, SD male rats (asthmatic rats)Dosage:30 mg/kg Administration:I.p.; for 7 days Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.
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同义词——
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通路Membrane Transporter/Ion Channel
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靶点TRP/TRPV Channel
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受体TRP/TRPV Channel
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研究领域——
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适应症——
化学信息
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CAS Number2415206-22-1
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分子量442.48
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分子式C24H25F3N4O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (226.00 mM; 超声助溶 )
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SMILESC(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. YunFeng Cheng, et al. Heteroaromatic acetamide derivative, and preparation and use thereof. WO2020244460A1.
