MSU-42011

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MSU-42011 是一种具有口服活性的类视黄醇 X 受体 (RXR) 激动剂。MSU-42011 可以有效抑制 iNOS 以及 p-ERK 蛋白水平的表达。MSU-42011 具有免疫调节和抗肿瘤活性。MSU-42011 可用于癌症的研究。

MSU-42011 is an orally active retinoid X receptor (RXR) agonist. MSU-42011 inhibits the iNOS activity and reduces the expression of p-ERK protein. MSU-42011 has immunomodulatory and antitumor activity.

RT-PCR Cell Line:HepG2 liver cancer cells Concentration:300 nM Incubation Time:8 h Result:SREBP expression ranged from no change to a 1.49-fold induction compared to the vehicle control.

Animal Model:A/J mice (Intraperitoneal injected with the carcinogen ethyl carbamate (0.32 mg/injection) for 8 weeks) Dosage:25 mg/kg Administration:Oral administration; One week after, i.p. every other week for a total of 6 injections with Carboplatin (HY-17393) (50 mg/kg) and paclitaxel (15 mg/kg); for 12 weeksResult:The number and size of detected lung surface tumors increased not in the treatment groupCombines with C/P was most effective in reducing tumor number (67% vs. control), tumor size (76% vs. control), and overall tumor burden (92% vs. control).Animal Model:A/J lung cancer model (Intraperitoneal injected with the carcinogen ethyl carbamate (0.32 mg/injection) for 8 weeks) Dosage:100 mg/kg Administration:Oral administration; After 2 weeks, each mouse was intraperitoneally injected with anti-PD1 and anti-PDL1 antibodies at a rate of 50 μg/mouse, twice a week for a total of 22 times Result:Showed that an increase in the ratio of anti-tumor CD8 T cells to CD4, CD25 T cells resulted in a significant reduction in tumor volume compared to MSU42011 or anti-PD(L)1 antibody alone.

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Immunology/Inflammation

NOS

NOS | Retinoid Receptor | PERK | Lipid | NO Synthase

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2456434-36-7

382.54

C24H34N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (326.76 mM; 超声助溶 (<60°C)

N(CC(C)C)(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)C2=CC=C(C(O)=O)C=N2

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(-20℃)

With Ice Pack

≥ 2 years