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Prezalumab
CAS No. 1523164-68-2
Prezalumab ( —— )
产品货号. M36911 CAS No. 1523164-68-2
Prezalumab (AMG 557) 是一种靶向 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 对系统性红斑狼疮关节炎有研究作用。Prezalumab 可用于干燥综合征皮肤红斑狼疮、银屑病和系统性红斑狼疮 (SLE) 的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥5567 | 有现货 |
|
| 10MG | ￥7496 | 有现货 |
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| 25MG | ￥10881 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Prezalumab
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Prezalumab (AMG 557) 是一种靶向 ICOSL 和 BAFF 的人源 IgG2 单克隆抗体。Prezalumab 对系统性红斑狼疮关节炎有研究作用。Prezalumab 可用于干燥综合征皮肤红斑狼疮、银屑病和系统性红斑狼疮 (SLE) 的研究。
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产品描述Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).
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体外实验——
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体内实验Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models.Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition.Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys.Cynomolgus MonkeysIV10 mg/kg,Cynomolgus MonkeysSC 10 mg/kg.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1523164-68-2
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分子量
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhang M, et al. Development of an ICOSL and BAFF bispecific inhibitor AMG 570 for systemic lupus erythematosus treatment. Clin Exp Rheumatol. 2019 Nov-Dec;37(6):906-914.?
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