Ezabenlimab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ezabenlimab (BI-754091) 是一种抗 PD-1 单克隆抗体，结合 PD-1 的 Kd 为 6 nM (CHO 细胞)。Ezabenlimab 能够阻断 PD-1 与 PD-L1 和 PD-L2 的相互作用。Ezabenlimab 还增加 T 细胞内的 γ 干扰素分泌，抑制体内肿瘤生长。

Ezabenlimab (BI-754091) is an anti-PD-1 mAb with binding constant Kd value of 6 nM (CHO cells). Ezabenlimab blocks the interaction of PD-1 with PD-L1 and PD-L2. Ezabenlimab increases interferon-γ secretion in T cells, and inhibits tumor growth in vivo.

Ezabenlimab inhibits the interaction of PD-1 to PD-L1 and PD-L2 in CHO cells with IC90s of 4.14 nM and 3.98 nM, respectively; and inhibits the interaction of PD-1 to PD-L1 and PD-L2 in cynomolgus with IC90s of 5.61 nM and 7.54 nM, respectively.Ezabenlimab increases IFN-γ secretion in primary human antigen-experienced CD3-positive T cells, with an EC50 value of 0.9 nM.Ezabenlimab (200 nM) has synergistic effect with BI 754111, resulting in further increase of IFN-γ secretion.

Ezabenlimab (0.3-30 mg/kg; i.p.; single dose or twice per week or every 3 weeks) inhibits tumor progress and shows comparable anti-tumor activity in hPD-1 knock-in mouse model.Animal Model:hPD-1 knock-in mouse model Dosage:0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg Administration:Intraperitoneal injection; single dose or twice per week or every 3 weeks Result:Showed tumor growth inhibition (TGI) at day 25 dose-dependently of 99%, 101%, 91%, 48%, and 44%, respectively.

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Others

Other Targets

Others

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2249882-54-8

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years