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Intetumumab
CAS No. 725735-28-4
Intetumumab ( —— )
产品货号. M36730 CAS No. 725735-28-4
Intetumumab (CNTO 95) 是一种有效的抗 EGFR 单克隆抗体，是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥5843 | 有现货 |
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| 10MG | ￥7866 | 有现货 |
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| 25MG | ￥11439 | 有现货 |
|
| 50MG | ￥15345 | 有现货 |
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| 100MG | ￥20070 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Intetumumab
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Intetumumab (CNTO 95) 是一种有效的抗 EGFR 单克隆抗体，是糖工程增强抗体依赖性细胞毒性 (ADCC)。Intetumumab 可用于癌症的研究。
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产品描述Intetumumab (CNTO 95) is a potent anti-EGFR monoclonal antibody that is glycoengineered for enhanced antibody-dependent cellular cytotoxicity (ADCC). Intetumumab can be used in research of cancer.
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体外实验Intetumumab (CNTO 95; 0-5 μg/mL; 20 min; USPC-ARK-3 cells) inhibits integrin-mediated USPC cell adherence to a vitronectin substratum and inhibits serum-induced migration of USPC cells.
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体内实验Intetumumab (CNTO 95; 10 mg/kg; i.p.; Male nude rats) inhibits tumor growth and inhibits spontaneous lung metastasis of A549 tumors and decreases both the number of rats with lung metastasis and the number of metastatic lesions per lung.Animal Model:Male nude rats with lung metastasis models (5-6 weeks old and 150-200 g)Dosage:10 mg/kg Administration:Intraperitoneal injection; once a week for 60 days Result:Had the total tumor response rates (CR and PR) was 33% in A549 tumor model.Developed lung metastases only 4 of 9 rats.
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同义词——
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通路Angiogenesis
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靶点EGFR
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受体EGFR
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研究领域——
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适应症——
化学信息
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CAS Number725735-28-4
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分子量145.6 (kDa)
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分子式——
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纯度>98% (HPLC)
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溶解度——
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bellone M, et, al. Expression of αV-integrins in uterine serous papillary carcinomas; implications for targeted therapy with intetumumab (CNTO 95), a fully human antagonist anti-αV-integrin antibody. Int J Gynecol Cancer. 2011 Aug;21(6):1084-90.?
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