Canakinumab ( —— )

产品货号. M36559 CAS No. 914613-48-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Canakinumab
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Canakinumab (ACZ885) 是一种重组的人抗 IL-1β 单克隆抗体。Canakinumab 显示出对人类和绒猴 IL-1β 的 IC50 值为分别为 43.6 和 40.8 pM。Canakinumab 的作用模式是基于对 IL-1β 信号的中和，从而抑制与自身免疫性疾病相关的炎症。
产品描述

Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.
体外实验

Canakinumab (0-7 nM) dose dependently represses IL-6 production in marmoset peripheral blood mononuclear cells with IC50s of 43.6 and 40.8 pM for human and marmoset IL-1β.Canakinumab effectively competes with IL-1RI and IL-1RII for binding to IL-1b.
体内实验

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同义词

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通路

Apoptosis
靶点

IL Receptor
受体

IL Receptor
研究领域

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适应症

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