TSPO ligand-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TSPO ligand-1 是 AUTAC4 (HY-134640) 的配体，可用于合成 PROTACs。TSPO ligand-1 是一种线粒体外膜跨膜结构域蛋白，可与 AUTAC4 相结合，调节线粒体自噬 (autophagy) 促进靶向线粒体更新。TSPO ligand-1 也可参与胆固醇从线粒体外膜到内膜的转运，作为脑损伤和神经变性的敏感生物标志物。

TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.

TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice.TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells.TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.

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Autophagy

Autophagy

Autophagy | Ligands for Target Protein for PROTAC

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4560-08-1

283.71

C16H10ClNO2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (440.59 mM; 超声助溶 )

O=C(Cl)C(=O)C=1C=2C=CC=CC2NC1C=3C=CC=CC3

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(-20℃)

With Ice Pack

≥ 2 years