CLK8

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CLK8 是一种有效且特异性的 CLOCK 抑制剂，可以破坏 CLOCK 和 BMAL1 之间的相互作用并干扰 CLOCK 的核转位。CLK8 可用于研究与昼夜节律减弱相关的疾病。

CLK8 is a potent and specific CLOCK inhibitor that can disrupt the interaction between CLOCK and BMAL1 and interfere with nuclear translocation of CLOCK. CLK8 can be used for the research of disorders associated with dampened circadian rhythms.

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Animal Model:Male C57BL/6J mice (8 weeks, 18-24 g)Dosage:25 mg/kg Administration:A single i.p.Result:A decrease in CLOCK levels was detected in whole cell lysates of the mouse livers, whereas the levels of BMAL1 and CRY1 were unaltered.Decreased the abundance of CLOCK in the nucleus.The abundances of cytosolic and nuclear BMAL1 and CRY1 were unaltered.Decreased Cry1 transcriptional level.

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Others

Other Targets

Others

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898920-65-5

498.53

C29H26N2O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (100.29 mM; 超声助溶 )

O=C1OC2=C(C(OCC(=O)NC=3C=CC=CC3C(=O)N)=CC=4OC(C)(C)CCC42)C(=C1)C=5C=CC=CC5

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(-20℃)

With Ice Pack

≥ 2 years