TASK-1-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TASK-1-IN-1 是一种有效的选择性的 TASK-1 (Potassium Channel) 抑制剂，IC50 为 148 nM。TASK-1-IN-1 对 TASK-3 通道 (IC50 为 1750 nM) 的抑制作用降低，并且对其他 K+ 通道没有显着影响。TASK-1-IN-1 具有抗癌作用。

TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel) inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects.

TASK-1-IN-1 (compound F3) blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells, indicating that it is acting in TASK-1 channels.Cell Proliferation Assay Cell Line:MCF-7 cells Concentration:10 μM Incubation Time:96 hours Result:Showed an antiproliferative activity of ～45% on the cell line MCF-7.

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Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

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600125-11-9

344.41

C22H20N2O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 66.67 mg/mL (193.58 mM; 超声助溶 )

N(C(=O)C1=CC(NC(=O)C2=CC=CC=C2)=CC=C1)C3=C(CC)C=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years