Vinaxanthone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vinaxanthone (SM-345431) 是一种有效的选择性 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，semaphorin3A 和 FabI的 IC50 分别为 0.1-0.2 μM 和 0.9 μM。Vinaxanthone 抑制底物(t-o-NAC thioester)和辅助因子 (NADPH)，Ki 分别为 3.1 μM 和 1.0 μM。Vinaxanthone 能够用于处理由多重耐药病原体引起的感染。

Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC50s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with Kis of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens.

Cell Viability AssayCell Line:mouse corneal epithelial cell line (TKE2)Concentration:0.1 mg/mL Incubation Time:24 hResult:Didn't affect cell viability by dose.Cell Proliferation Assay Cell Line: TKE2 Concentration:0.01-1 mg/mL Incubation Time:24 h Result:Showed a slight dose-dependent inhibition on cell proliferation.Immunofluorescence Cell Line:mouse podocytes Concentration:0.5 μM Incubation Time:20 min Result:Exhibited less C-Caspase3-positive cells.Western Blot Analysis Cell Line:HK-2 cells Concentration:0.1-1 μM Incubation Time:24 h Result:Decreased the expression of E-cadherin.Increased the expression of ɑ-SMA and vimentin.

Animal Model:murine corneal transplantation modelDosage:0.1 mg/mLAdministration: Subconjunctival injections, every 2 days, 3 weeks Result:Showed significantly higher nerve growth.Improved the corneal sensitivity.Animal Model: mouse model of Doxorubicin (10 mg/kg)-induced podocytopathy Dosage:20 μg Administration:Intraperitoneal injection (i.p.), every day Result:Improved the expression of nephrin.Reduced podocytopathy and tubular casts.Detected rarely TUNEL-positive cells in the Dox + Vinaxanthone group.Had fewer p-c-Jun-positive cells in the Dox + Vinaxanthone group.

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Metabolic Enzyme/Protease

Phospholipase

Phospholipase | Antibacterial

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133293-89-7

576.42

C28H16O14

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (173.48 mM; 超声助溶 )

C(C)(=O)C=1C(=C(C(C)=O)C=C2C1OC=3C(C2=O)=C(C(O)=O)C(O)=C(O)C3)C=4C(=O)C=5C(OC4)=CC(O)=C(O)C5C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years