Elgodipine
CAS No. 119413-55-7
Elgodipine ( —— )
产品货号. M36162 CAS No. 119413-55-7
Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun. The Elgodipine-induced inhibition was voltage-dependent. Elgodipine is a potential compound for the treatment of angina pectoris.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ¥877 | 有现货 |
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| 10MG | ¥1311 | 有现货 |
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| 25MG | ¥2093 | 有现货 |
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| 50MG | ¥3041 | 有现货 |
|
| 100MG | ¥4212 | 有现货 |
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| 200MG | ¥5625 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Elgodipine
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun. The Elgodipine-induced inhibition was voltage-dependent. Elgodipine is a potential compound for the treatment of angina pectoris.
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产品描述Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun. The Elgodipine-induced inhibition was voltage-dependent. Elgodipine is a potential compound for the treatment of angina pectoris.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number119413-55-7
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分子量524.58
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分子式C29H33FN2O6
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纯度>98% (HPLC)
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溶解度——
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SMILESC(OCCN(CC1=CC=C(F)C=C1)C)(=O)C=2C(C(C(OC(C)C)=O)=C(C)NC2C)C3=C4C(=CC=C3)OCO4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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BMS986260
BMS-986260 是一种选择性、口服生物可利用的 TGFβR1 抑制剂 (IC50 = 1.6 nM)。 BMS-986260 在多种 TGFβ 依赖性细胞测定中表现出功能活性、优异的激酶组选择性、良好的药代动力学特性以及与抗 PD-1 抗体联合在小鼠结直肠癌 (CRC) 模型中的体内疗效。
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CALP1
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
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