DHODH-IN-23

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DHODH-IN-23 (Compound A) 是一种具有口服活性的 DHODH 抑制剂，可用于癌症的研究。

DHODH-IN-23 (Compound A) is an orally active DHODH inhibitor that can be used for the research of cancer.

Cell Proliferation Assay Cell Line:U937, HL-60, THP-1, KG-1 and MV411 Concentration:Incubation Time:72 h Result:Inhibited cell growth with GI50s of 2.4, 2.5, 2.5, 3.5 and 7.6 μM against U937, THP-1, MV411 HL-60 and KG-1, respectively.RT-PCR Cell Line:THP-1 cells Concentration:72 h Incubation Time:0.1, 1 and 3 μM Result:Induced CDllb mRNA expression.

Animal Model:MV411 mouse xenograft model Dosage:30 mg/kg Administration:Oral administration, twice daily for 21 days Result:Demonstrated significant anti-tumor activity both as a single agent and in combination with Cytarabine (HY-13605) at 20 mg/kg with tumor growth inhibitions of 37 and 73% respectively.

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Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase

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1346705-53-0

441.88

C24H21ClFNO4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (282.88 mM; 超声助溶 )

ClC=1C=C(C=C(F)C1NC(=O)C2=C(C(O)=O)C=CC=C2)C3=CC(OCCCC)=CC=C3

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(-20℃)

With Ice Pack

≥ 2 years