Enpp/Carbonic anhydrase-IN-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Enpp/Carbonic anhydrase-IN-1 (compound 1e) 是一种有效的 Enpp 和 carbonic anhydrase 抑制剂，对 NPP1、NPP2、NPP3、CA-II、CA-IX 的 IC50 值分别 1.36、1.35、3.00、0.88、1.02 μM。Enpp/Carbonic anhydrase-IN-1 对癌细胞具有抗增殖活性，对正常细胞具有低细胞毒性。Enpp/Carbonic anhydrase-IN-1 诱导细胞凋亡 (Apoptosis)。

Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis.

Enpp/Carbonic anhydrase-IN-1 (compound 1e) (0-100 μM; ) inhibits some cancer cells growth with IC50s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 μM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively.Enpp/Carbonic anhydrase-IN-1 (0-2 μM) shows low cytotoxic against normal breast epithelial cells (HME1) and normal skin fibroblast cells (F180) with IC50s of > 50 μM.Enpp/Carbonic anhydrase-IN-1 (0.32, 0.64 μM) induces apoptosis in a dose-dependent manner at K-562 cells.Cell Proliferation Assay Cell Line:K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells Concentration:0-100 μM Incubation Time:Result:Inhibited the cell growth with IC50s of 0.32, 0.40, 0.58, 0.87, 0.40, 0.96 μM for K-562, RPMI-8226, SR, COLO 205, HT-29, SF-539 cells, respectively.Apoptosis Analysis Cell Line:K-562 cells Concentration:0.32, 0.64 μM Incubation Time:Result:Induced apoptosis in a dose-dependent manner.

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Membrane Transporter/Ion Channel

Carbonic Anhydrase

Carbonic Anhydrase | PDE

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2883495-35-8

411.51

C23H25NO4S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (243.01 mM; 超声助溶 (<50°C)

O=C(Nc1ccc(OS(=O)(=O)c2ccccc2)cc1)C12CC3CC(CC(C3)C1)C2

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(-20℃)

With Ice Pack

≥ 2 years