Tiotropium Bromide hydrate B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tiotropium bromide (BA-679 BR) monohydrate 是长效的毒蕈碱受体拮抗剂。

Tiotropium bromide monohydrate is an anticholinergic and bronchodilator and a muscarinic receptor antagonist.Target: mAChR Tiotropium bromide (Ba 679 BR) is a novel potent and long-lasting muscarinic antagonist that has been developed for the treatment of chronic obstructive airways disease (COPD). Binding studies with [3H]tiotropium bromide in human lung have confirmed that this is a potent muscarinic antagonist with equal affinity for M1-, M2- and M3-receptors and is approximately 10-fold more potent than ipratropium bromide. In vitro tiotropium bromide has a potent inhibitory effect against cholinergic nerve-induced contraction of guinea-pig and human airways, that has a slower onset than atropine or ipratropium bromide. tiotropium bromide dissociates slowly from M3-receptors (on airway smooth muscle) but rapidly from M2 autoreceptors (on cholinergic nerve terminals) . Tiotropium bromide is a quaternary ammonium derivative that binds to muscarinic receptors. However, although tiotropium binds with high affinity to muscarinic receptors of M1-, M2- and M3-subtypes, it dissociates very slowly from M1- and M3-receptors but more rapidly from M2-receptors, thereby giving it a unique kinetic selectivity .

——

——

——

Cell Cycle/DNA Damage

AChR

AChR

——

——

411207-31-3

490.43

C19H24BrNO5S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (203.90 mM; 超声助溶 (<60°C)

O.[Br-].[H][C@]12C[C@@H](C[C@]([H])([C@H]3O[C@@H]13)[N+]2(C)C)OC(=O)C(O)(c1cccs1)c1cccs1

——

(-20℃)

With Ice Pack

≥ 2 years