KS106

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KS106 是一种有效的 ALDH 抑制剂，对 ALDH1A1、ALDH2 和 ALDH3A1 的 IC50 分别为 334、2137、360 nM。KS106 具有低毒性的抗增殖和抗癌作用。KS106 显著增加 ROS 活性、脂质过氧化和有毒醛的积累。KS106 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G2/M 期。

KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.

KS106 (compound 3h) (0-100 μM; 72 h) shows anti-proliferative activity with IC50s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 μM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively.KS106 (5 μM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase.Apoptosis Analysis Cell Line:HCT116, HT29 cells Concentration:5 μM Incubation Time:24 h Result:Induced cell apoptosis.Cell Cycle Analysis Cell Line:HCT116 cells Concentration:5 μM Incubation Time:24 h Result:Induced cell cycle arrest at G2/M phase.

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Apoptosis

Apoptosis

Apoptosis | Dehydrogenase

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2408477-50-7

474.3

C18H15BrF3N3O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (210.84 mM; 超声助溶 )

Br.NC(=N)SCc1ccc(CN2C(=O)C(=O)c3cc(ccc23)C(F)(F)F)cc1

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(-20℃)

With Ice Pack

≥ 2 years