HOIPIN-8 sodium ( —— )

产品货号. M35672 CAS No. 2519537-70-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

HOIPIN-8 sodium
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
产品描述

HOIPIN-8 is a potent inhibitor of the linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. As a derivative of HOIPIN-1, it exhibits 255-fold greater inhibition of both petit-LUBAC and TNF-α-mediated NF-κB activation compared to HOIPIN-1. HOIPIN-8 is a promising tool to explore cellular functions of LUBAC.
体外实验

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体内实验

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同义词

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通路

Immunology/Inflammation
靶点

IκB kinase (IKK)
受体

IκB/IKK
研究领域

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适应症

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CAS Number

2519537-70-1
分子量

456.38
分子式

C23H15F2N4NaO3
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(C=C(C4=CNN=C4)C=C3F)F)=O)[O-].[Na+]
化学全称

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