AMPK-IN-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AMPK-IN-3 (化合物 67) 是一种强效的、选择性的 AMPK 抑制剂，其对AMPK (α2)、AMPK (α1) 和 KDR 的 IC50 值分别为 60.7、107 和 3820 nM。AMPK-IN-3 对 AMPK 的抑制不影响细胞活力或导致 K562 细胞的明显细胞毒性。AMPK-IN-3 可用于癌症的研究。

AMPK-IN-3 (compound 67) is a potent and selective AMPK inhibitor with IC50s of 60.7, 107 and 3820 nM for AMPK (α2), AMPK (α1) and KDR, respectively. AMPK-IN-3 inhibits AMPK does not affect cell viability or cause significant cytotoxicity in K562 cells. AMPK-IN-3 can be used in study of cancer.

AMPK-IN-3 (100 nM) shows inhibition values for AMPK(α2), FLT1, JAK1 JH2-pseudokinase and AMPK(α1) for 64%, 43%, 41% and 29%, respectively.AMPK-IN-3 (0.195313, 0.78125, 3.125, 12.5, 50 μM; 2 h) decreases the level of p-ACC in K562 cells.AMPK-IN-3 (1-100 μM; 24, 48, 72 h) shows potent inhibition of cellular AMPK activity but not affect cell viability.Cell Viability Assay Cell Line:K562 cells Concentration:0.195313, 0.78125, 3.125, 12.5, 50 μM Incubation Time:2 h Result:Decreased cellular levels of p-ACC(Ser79) in K562 cells.Cell Viability Assay Cell Line:K562 cells Concentration:1-100 μM Incubation Time:24, 48, 72 h Result:Showed no measurable impact on cell viability in K562 cells cultured under hypoxic conditions for 72 hours.

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Angiogenesis

VEGFR

VEGFR | AMPK

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2417674-27-0

451.56

C25H33N5O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 115 mg/mL (254.67 mM; 超声助溶 )

CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(CCC(N)=O)cc23)c1C

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(-20℃)

With Ice Pack

≥ 2 years