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SHMT-IN-2
CAS No. 2102681-49-0
SHMT-IN-2 ( —— )
产品货号. M35638 CAS No. 2102681-49-0
SHMT-IN-2 是一种特异性人SHMT1/2 抑制剂，对 SHMT1 和 SHMT2 的 IC50 值分别为 13 nM 和 66 nM。SHMT-IN-2 可以抑制许多人类癌细胞的生长，对 B 细胞淋巴瘤有敏感性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1729 | 有现货 |
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| 10MG | ￥2736 | 有现货 |
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| 25MG | ￥4362 | 有现货 |
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| 50MG | ￥6110 | 有现货 |
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| 100MG | ￥7974 | 有现货 |
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| 200MG | ￥10710 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1644 | 有现货 |
|
生物学信息
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产品名称SHMT-IN-2
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述SHMT-IN-2 是一种特异性人SHMT1/2 抑制剂，对 SHMT1 和 SHMT2 的 IC50 值分别为 13 nM 和 66 nM。SHMT-IN-2 可以抑制许多人类癌细胞的生长，对 B 细胞淋巴瘤有敏感性。
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产品描述SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas.
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体外实验SHMT-IN-2 (compound 2) can inhibit cell growth with cellular IC50 values of 2800 nM and 36 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 (30 μM) shows the growth sensitivity with the median IC50 was 4 μM to a panel of nearly 300 human cancer cell lines (with IC50 values of 1.72 μM and 1.73 μM for CCRF-CEM and HT,respectively), cell lines of B-cell lymphoma origin were enriched in the more sensitive half of cells.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2102681-49-0
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分子量431.45
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分子式C22H24F3N5O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (231.78 mM; 超声助溶 )
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SMILESCC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C(F)(F)F)N1CCCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. regory S Ducker, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409.?
