021-51111890
购物车（）
sales@molnova.cn
KRAS G12D inhibitor 14
CAS No. 2765254-39-3
KRAS G12D inhibitor 14 ( —— )
产品货号. M35624 CAS No. 2765254-39-3
KRAS G12D inhibitor 14 是一种有效的 KRAS G12D 抑制剂，与 KRAS G12D蛋白结合的 KD 为 33 nM。KRAS G12D inhibitor 14 降低 KRAS G12D (KRAS G12D-GTP) 的活性形式，但不降低 KRAS G13D。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称KRAS G12D inhibitor 14
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述KRAS G12D inhibitor 14 是一种有效的 KRAS G12D 抑制剂，与 KRAS G12D蛋白结合的 KD 为 33 nM。KRAS G12D inhibitor 14 降低 KRAS G12D (KRAS G12D-GTP) 的活性形式，但不降低 KRAS G13D。
-
产品描述KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D.
-
体外实验KRAS G12D inhibitor 14 (compound KD-8) shows antiproliferative activity with an IC50 of 2.1 μM against three KRAS G12D-mutated cells (Panc1, SW1990 and CT26). KRAS G12D inhibitor 14 decreases the active form of KRAS (KRAS-GTP) in KRAS G12D mutated cancer cell lines (CT26 and SW1990) but not in KRAS G13D mutated cancer cell lines (HCT116). KD-8 also causes efficient apoptosis of SW1990 and CT26 cancer cells. KRAS G12D inhibitor 14 down-regulates the phosphorylated Raf and Erk in CT26 and SW1990 cancer cell lines but not in HeLa cells (KRAS WT).
-
体内实验KRAS G12D inhibitor 14 (compound KD-8) (40 mg/kg or 60 mg/kg; i.p.) exhibits significant antitumor efficacy in a CT26 tumor model with a tumor growth inhibition (TGI) of 42% or 53% without causing apparent toxicity.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Kras
-
研究领域——
-
适应症——
化学信息
-
CAS Number2765254-39-3
-
分子量420.45
-
分子式C20H19F3N4OS
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (118.92 mM; 超声助溶 (<60°C)
-
SMILESO(C)C1=C(C2=CC3=C(N=CN=C3S2)N4C5CCC(C4)NC5)C=C(C(F)(F)F)C=C1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
-
CYP11B2-IN-1
CYP11B2-IN-1 是一种 CYP11B2 抑制剂，IC50 为 2.3 nM。 CYP11B2-IN-1 抑制 CYP11B1，IC50 为 142 nM。
-
Sodium Hydrogen Sulf...
Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sulfide (hydrate) is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration, reduces airway inflammation, and protects neurites, heart, and intestine from chemical or ischemic-reperfusion damage.
-
Nonanal
Nonanal is a growth factor for wood-rotting fungi. Nonanal is a potential attractant for the pine shoot beetle.
