ZINC12409120 ( —— )

产品货号. M35513 CAS No. 1010888-06-8

ZINC12409120 是一种高选择性的 ERK 抑制剂。ZINC12409120 通过干扰 FGF23:α-Klotho 的相互作用而抑制 ERK 活性，IC50 为 5.0 μM。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥5349	有现货
10MG	￥7401	有现货
25MG	￥10416	有现货
50MG	￥12834	有现货
100MG	￥15750	有现货
500MG	￥31320	有现货
1G	获取报价	有现货

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生物学信息

产品名称

ZINC12409120
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ZINC12409120 是一种高选择性的 ERK 抑制剂。ZINC12409120 通过干扰 FGF23:α-Klotho 的相互作用而抑制 ERK 活性，IC50 为 5.0 μM。
产品描述

ZINC12409120 is a high selective ERK inhibitor. ZINC12409120 acts on disrupting FGF23:α-Klotho interaction to inhibit ERK activity with an IC50 of 5.0 μM.
体外实验

FGF23 induces hypophosphatemia, mediated by ternary complex formed by FGF23, the FGF receptor (FGFR), and α-Klotho.ZINC12409120 (1 nM-0.1 mM; 5 h) inhibits ERK reporter activities mediated by FGF23 (1 μM), with an IC50 of 5 μM.ZINC12409120 (10 μM; 5 h) specificaly inhibits ERK activity mediated by FGF23:α-Klotho instead of EGF-mediated ERK activation, and exhibits no inhibitory effect on EGFR tyrosine kinase or EGF/EGFR interaction.ZINC12409120 has an half-life of 8.4 h, predicted by pkCSM64 .Cell Proliferation Assay Cell Line:Human embryonic kidney (HEK) 293T cells Concentration:1 nM-0.1 mM Incubation Time:5 hours Result:Inhibited FGF23-mediated ERK reporter activity in a dose-dependent manner, with an IC50 of 5 μM. And reduced FGF23-mediated ERK activities by 70%, as well.
体内实验

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同义词

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通路

MAPK/ERK Signaling
靶点

ERK
受体

ERK
研究领域

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适应症

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化学信息

CAS Number

1010888-06-8
分子量

344.37
分子式

C20H16N4O2
纯度

>98% (HPLC)
溶解度

——
SMILES

C(=O)(C1=NC(C2=C3C(NC=C3)=CC=C2)=NO1)N4CC=5C(CC4)=CC=CC5
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Liu SH, et al. Identification of Small-Molecule Inhibitors of Fibroblast Growth Factor 23 Signaling via In Silico Hot Spot Prediction and Molecular Docking to α-Klotho. J Chem Inf Model. 2022 Jul 22.?

计算器

浓度计算器

摩尔计算器

分子量计算器

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