Disulfamide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Disulfamide，一种具有口服活性的利尿剂，碳酸酐酶 (carbonic anhydrase) 抑制剂，其 IC50 值为 0.07 μM。Disulfamide 可通过抑制碳酸酐酶，阻止钠、碳酸氢盐在近曲小管中的重吸收，从而导致利尿。

Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC50 value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule.

——

Disulfamide (intraperitoneal injection, 200 mg/kg, once) has potential blood glucose raising properties in male Wistar rats.Animal Model:Male Wistar rats weighing between 200-300 g Dosage:200 mg/kg Administration: Intraperitoneal injection; once Result:Resulted in elevated blood sugar levels from an initial blood glucose concentration of 143.1 mg/100 mL to a one hour later final concentration of 194.6 mg/100 mL, an increase of 36%.

——

Membrane Transporter/Ion Channel

Carbonic Anhydrase

Carbonic Anhydrase

——

——

671-88-5

284.74

C7H9ClN2O4S2

>98% (HPLC)

——

S(N)(=O)(=O)C1=CC(S(N)(=O)=O)=C(Cl)C=C1C

——

(-20℃)

With Ice Pack

≥ 2 years