Terodiline

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Terodiline 是一种解痉剂，可阻断 hERG 电流，IC50 为 375 nM。Terodiline 具有抗胆碱能 (anticholinergic) 和钙拮抗剂 (calcium) 特性，可有效减少逼尿肌不稳定引起的异常膀胱收缩，可用于尿失禁的研究。

Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM.?Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability.?Terodiline can be used for the research of urinary incontinence.

——

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg).Animal Model:Fmale or male Hartley guinea pigs (200-600 g)Dosage:80 mg/kg Administration:Administered S.C. Result:Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.

——

Cell Cycle/DNA Damage

AChR

AChR | HER | Calcium Channel

——

——

15793-40-5

281.44

C20H27N

>98% (HPLC)

——

C=1C=CC(=CC1)C(C=2C=CC=CC2)CC(NC(C)(C)C)C

——

(-20℃)

With Ice Pack

≥ 2 years