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PNU-282987 free base
CAS No. 711085-63-1
PNU-282987 free base ( —— )
产品货号. M35418 CAS No. 711085-63-1
PNU-282987 (free base) 是一种有效的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，EC50 为 154 nM。 PNU-282987 (free base) 也是 5-HT3 受体的功能性拮抗剂，IC50 为 4541 nM。PNU-282987 (free base) 可用于中枢和外周神经系统的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥748 | 有现货 |
|
| 10MG | ￥1406 | 有现货 |
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| 25MG | ￥2697 | 有现货 |
|
| 50MG | ￥5013 | 有现货 |
|
| 100MG | ￥6822 | 有现货 |
|
| 500MG | ￥13410 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PNU-282987 free base
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述PNU-282987 (free base) 是一种有效的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，EC50 为 154 nM。 PNU-282987 (free base) 也是 5-HT3 受体的功能性拮抗剂，IC50 为 4541 nM。PNU-282987 (free base) 可用于中枢和外周神经系统的研究。
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产品描述PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems.
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体外实验PNU-282987 (free base) (Compound C7) displaces the R7 selective antagonist methyllycaconitine (MLA) from rat brain homogenates with a Ki of 27 nM.PNU-282987 has α7 nAChR agonist activity with an EC50 of 154 nM.PNU-282987 also has inhibition for the 5-HT3 receptor with an IC50 value of 4541nM.
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体内实验PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit.PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner.Animal Model:Rats Dosage:1, 3 mg/kg Administration:i.v. Result:Significantly reversed amphetamine-induced gating deficit.
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同义词——
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通路Cell Cycle/DNA Damage
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靶点AChR
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受体AChR | 5-HT Receptor
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研究领域——
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适应症——
化学信息
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CAS Number711085-63-1
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分子量264.75
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分子式C14H17ClN2O
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纯度>98% (HPLC)
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溶解度——
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SMILESClc1ccc(cc1)C(=O)N[C@H]1CN2CCC1CC2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8. ?
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