TG003 B

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TG003 是一种高效的 Clk1/Sty 抑制剂，抑制 Clk1 和 Clk4 的 IC50 值分别为 20 和 15 nM。

TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively.

TG003, shows the most potent effect on Clk1/Sty and Clk4 (IC50, 15–20 nM) and lesser on Clk2 (200 nM). TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA in vitro by suppression of Clk-mediated phosphorylation. It suppresses serine/arginine-rich protein phosphorylation, dissociation of nuclear speckles, and Clk1/Sty-dependent alternative splicing in mammalian cells. The small drug TG003 increases endogenous expression of p53β and p53γ protein isoforms by modulation of TP53 intron 9 alternative splicing.

Intrathecal injection of either TG003 (1-100 pM) or IC261 (0.1-1 nM) dose-dependently decreases mechanical allodynia and thermal hyperalgesia induced by carrageenan or CFA.

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Cell Cycle/DNA Damage

CDK

CDK

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719277-26-6

249.33

C13H15NO2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (501.34 mM; 超声助溶 )

C(C)N\1C=2C(S/C1=C\C(C)=O)=CC=C(OC)C2

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(-20℃)

With Ice Pack

≥ 2 years