021-51111890
购物车（）
sales@molnova.cn
IndiMitecan
CAS No. 915360-05-3
IndiMitecan ( —— )
产品货号. M35375 CAS No. 915360-05-3
Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2043 | 有现货 |
|
| 10MG | ￥3126 | 有现货 |
|
| 25MG | ￥5013 | 有现货 |
|
| 50MG | ￥7022 | 有现货 |
|
| 100MG | ￥8883 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称IndiMitecan
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Indimitecan (LMP776) 是一种拓扑异构酶 I (Top1) 抑制剂，具有抗癌活性。
-
产品描述Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.
-
体外实验Indimitecan (LMP776) (0-100 μM) shows antiproliferative potencies against various human cancer cell lines, with mean-graph midpoint (MGM) of 0.079 ± 0.023 μM.Indimitecan shows potent DNA cleavage due to Top1 inhibition.Indimitecan can be substrates for metabolic ketone reductases.Cell Proliferation Assay Cell Line:HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145, MCF-7Concentration:0-100 μM Incubation Time: Result:Showed growth inhibition with GI50s of <0.01, <0.01, 0.04, <0.01, 0.08, <0.01, <0.01 and 0.01 μM against HOP-62, HCT-116, SF-539, UACC-62, OVCAR-3, SN12C, DU-145 and MCF-7 cells, respectively. And the mean-graph midpoint (MGM) for growth inhibition of all human cancer cell lines successfully tested (the National Cancer Institute’s developmental therapeutics assay (the “NCI60”)) was 0.079 ± 0.023 μM.
-
体内实验——
-
同义词——
-
通路Cell Cycle/DNA Damage
-
靶点Topoisomerase
-
受体Topoisomerase
-
研究领域——
-
适应症——
化学信息
-
CAS Number915360-05-3
-
分子量459.45
-
分子式C25H21N3O6
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 8.33 mg/mL (18.13 mM; 超声助溶 (<60 ℃)；酸性条件溶解 (HCL 调节，pH=3)
-
SMILESCOc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCn3ccnc3)c(=O)c2cc1OC
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Cinelli MA, et al. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as to?
产品手册
关联产品
-
Nifurpirinol
Nifurpirinol (P-7138) 是一种硝基芳香抗生素 (antibiotic)，是细菌硝基还原酶 (NTR) 的底物。与甲硝唑相比，Nifurpirinol 是一种更有效的 prodrug，可在表达硝基还原酶的转基因模型中诱导细胞消融。
-
Chloroquinoxaline su...
Chloroquinoxaline sulfonamide (Chloroquinoxaline) 是 sulfaquinoxaline 的结构类似物，是拓扑异构酶 II alpha/beta (topoisomerase II alpha/beta) 毒物。Chloroquinoxaline sulfonamide 用于控制家禽，兔，绵羊和牛的球虫病。 具有抗肿瘤活性。
-
Topoisomerase II inh...
Topoisomerase II inhibitor 14 (compound 2f) 是拓扑异构酶 II 的有效抑制剂，具有抗癌活性。Topoisomerase II inhibitor 14 诱导细胞凋亡，并将细胞周期阻滞在 S 期。Topoisomerase II inhibitor 14 具有抗氧化作用并降低 GSH、MDA 和 NO 的水平。
