UNC7467

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UNC7467 是一种有效的 IP6K抑制剂，IP6K2、IP6K1 和 IP6K6 的 IC50 值分别为 4.9、8.9 和1320 nM。UNC7467 可降低肌醇焦磷酸盐的水平。UNC7467 可用于肥胖研究。

UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research.

UNC7467 (2.5 μM; 3 hours; HCT116 cells) reduces levels of inositol pyrophosphates. UNC7467 reduces 5-InsP7 levels by 81% and 5-InsP8 levels by 63%.

UNC7467 (5 mg/kg; i.p.; daily, for 4 weeks; diet-induced obesity mice) ameliorated diet induced obesity, insulin resistance, and hepatic steatosis.UNC7467 (1-5 mg/kg; i.v. and i.p.; diet-induced obesity mice) exhibits low clearance (13.7 (mL/min)/kg) and large AUClast (6054 h?ng/mL for intra venous (i.v.) and 2527 h?ng/mL for intraperitoneal (i.p.)) in mice at 5 mg/kg dose.Animal Model:Diet-induced obesity (DIO) mice Dosage:5 mg/kg Administration:Intraperitoneal injection; daily, for 4 weeks Result:Improved glycemic profiles, ameliorated hepatic steatosis, and reduced weight gain without altering food intake.

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Others

Other Targets

Others

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2922283-43-8

315.32

C20H13NO3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 14.29 mg/mL (45.32 mM; 超声助溶 (<60°C)

O=C(O)C1=CC2=C(C3=CC=C(C4=CC=CC=C4)C=C3)ON=C2C=C1

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(-20℃)

With Ice Pack

≥ 2 years