021-51111890
购物车（）
sales@molnova.cn
PBRM1-BD2-IN-2
CAS No. 2819989-57-4
PBRM1-BD2-IN-2 ( —— )
产品货号. M35349 CAS No. 2819989-57-4
PBRM1-BD2-IN-2 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-2 对 PBRM1-BD2 具有结合亲和力和抑制活性， Kd 和 IC50 值分别为 9.3 μM 和 1.0 μM。PBRM1-BD2-IN-2 可用于癌症的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1701 | 有现货 |
|
| 10MG | ￥2499 | 有现货 |
|
| 25MG | ￥3850 | 有现货 |
|
| 50MG | ￥5292 | 有现货 |
|
| 100MG | ￥6912 | 有现货 |
|
| 500MG | ￥13770 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1568 | 有现货 |
|
生物学信息
-
产品名称PBRM1-BD2-IN-2
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述PBRM1-BD2-IN-2 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-2 对 PBRM1-BD2 具有结合亲和力和抑制活性， Kd 和 IC50 值分别为 9.3 μM 和 1.0 μM。PBRM1-BD2-IN-2 可用于癌症的研究。
-
产品描述PBRM1-BD2-IN-2 is a selective and cell-activepolybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer.
-
体外实验PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively.PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM.Cell Viability Assay Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1Concentration:0, 0.1, 1, and 10 μM Incubation Time:5 days Result:Inhibited LNCaP growth at higher concentrations.
-
体内实验——
-
同义词——
-
通路Chromatin/Epigenetic
-
靶点Epigenetic Reader Domain
-
受体Epigenetic Reader Domain
-
研究领域——
-
适应症——
化学信息
-
CAS Number2819989-57-4
-
分子量311.14
-
分子式C14H9Cl2FN2O
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESO=C1C=2C(NC(N1)C3=C(Cl)C=CC=C3F)=CC=CC2Cl
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Shifali Shishodia, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13.?
