PROTAC PD-1/PD-L1 degrader-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PROTAC PD-1/PD-L1 degrader-1，基于 Cereblon E3配体的 PD-1/PD-L1 PROTAC，抑制 PD-1/PD-L1 相互作用，IC50 为 39.2 nM。PROTAC PD-1/PD-L1 degrader-1 可显着恢复在 Hep3B/OS-8/hPD-L1 和 CD3 T 细胞共培养模型中抑制的免疫力。PROTAC PD-1/PD-L1 degrader-1 以溶酶体依赖性方式适度降低 PD-L1 的蛋白质水平。

PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.

PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%.PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively.Western Blot Analysis Cell Line:MDA-MB-231 cells Concentration:1-10 μM Incubation Time:24 hours Result:Reduced PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively.

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Others

Other Targets

PROTACs | PD-1/PD-L1

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2447066-37-5

1076.59

C59H58ClN7O11

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 210 mg/mL (195.06 mM; 超声助溶 )

N#CC1=CC=CC(=C1)COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(Cl)C=C2CN6CCCCC6C(=O)N7CCN(C(=O)CCCC(=O)NC8=CC=CC=9C(=O)N(C(=O)C89)C%10C(=O)NC(=O)CC%10)CC7

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(-20℃)

With Ice Pack

≥ 2 years