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AMPC
CAS No. 2254434-33-6
AMPC ( —— )
产品货号. M35156 CAS No. 2254434-33-6
AMPC 是一种有效的 TFF3 抑制剂。在 TFF3 阳性的 CMS4 结直肠癌细胞中，AMPC 可抑制细胞增殖、存活、致瘤性和 CSC 样行为。AMPC 作为一种潜在的抗癌试剂，可以单独或和 5-FU 联合使用，用于癌症研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
|
| 10MG | ￥1729 | 有现货 |
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| 25MG | ￥2762 | 有现货 |
|
| 50MG | ￥4204 | 有现货 |
|
| 100MG | ￥5787 | 有现货 |
|
| 500MG | ￥11520 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称AMPC
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AMPC 是一种有效的 TFF3 抑制剂。在 TFF3 阳性的 CMS4 结直肠癌细胞中，AMPC 可抑制细胞增殖、存活、致瘤性和 CSC 样行为。AMPC 作为一种潜在的抗癌试剂，可以单独或和 5-FU 联合使用，用于癌症研究。
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产品描述AMPC is a potent and effective TFF3 inhibitor. AMPC inhibits cell proliferation, survival, oncogenicity, and CSC-like behaviour in TFF3-positive CMS4 CRC cells. AMPC acts as a potential anti-cancer agent alone or in combination with 5-FU, and can be used for cancer research.
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体外实验AMPC decreases cell proliferation in CMS4 CRC cells, the IC50 values are 2.63 μM, 4.65 μM, and 69.69 μM, respectively in SW620 (high TFF3 expression), Caco-2, SW480 cells (low TFF3 expression), respectively.AMPC (1-10 μM) significantly reduces the total cellular levels of TFF3 in SW620 and Caco2 cells in a dose dependent manner.AMPC induces apoptosis in a dose dependent manner by the inhibition of TFF3, it induces a decrease in the S-phase population and increases caspase3/7 activity compared with control cells..
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体内实验AMPC (intraperitoneal injection; 40 mg/kg; once daily) leads to a significant reduction of tumour volume in AMPC-treated mice as compared to vehicle-treated mice from day 11 onward. AMPC results in larger areas of tumour necrosis and increased area of cells with apoptotic features in SW620 tumours. AMPC also significantly reduces tumour and serum TFF3 levels in vivo.Animal Model:SW620 cells are subcutaneously injected into nude mice Dosage:40 mg/kg Administration:Intraperitoneal injection; 40 mg/kg; once dailyResult:Lead to tumor decreasein vivo.Results in a marked reduction of Ki67 expression in tumor.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2254434-33-6
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分子量425.41
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分子式C25H16FN3O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 115 mg/mL (270.33 mM; 超声助溶 )
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SMILESN#CC1=C(OC=2C=3C=CC=CC3OC(=O)C2C1C4=CC=C(C=C4)C=5C=NC(F)=C(C5)C)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ru-Mei Chen, et al. Pharmacological Inhibition of TFF3 Enhances Sensitivity of CMS4 Colorectal Carcinoma to 5-Fluorouracil through Inhibition of p44/42 MAPK. Int J Mol Sci. 2019 Dec 9;20(24):6215?
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