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AHR antagonist 5 free base
CAS No. 2247950-42-9
AHR antagonist 5 free base ( —— )
产品货号. M35152 CAS No. 2247950-42-9
AHR antagonist 5 free base 是一种选择性的、具有口服活性的芳烃受体 (AHR) 抑制剂。AHR antagonist 5 free base 有效阻止 AHR 从细胞质转移到细胞核。AHR antagonist 5 free base 对 AHR 的选择性高于其他受体、转运蛋白和激酶，并具有抗癌作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3306 | 有现货 |
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| 10MG | ￥4712 | 有现货 |
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| 25MG | ￥7031 | 有现货 |
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| 50MG | ￥9179 | 有现货 |
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| 100MG | ￥12330 | 有现货 |
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| 200MG | ￥16650 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥3667 | 有现货 |
|
生物学信息
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产品名称AHR antagonist 5 free base
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述AHR antagonist 5 free base 是一种选择性的、具有口服活性的芳烃受体 (AHR) 抑制剂。AHR antagonist 5 free base 有效阻止 AHR 从细胞质转移到细胞核。AHR antagonist 5 free base 对 AHR 的选择性高于其他受体、转运蛋白和激酶，并具有抗癌作用。
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产品描述AHR antagonist 5 free base is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. AHR antagonist 5 free base effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases.
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体外实验AHR antagonist 5 free base (Compound A) potently inhibits AHR activity in human and rodent cell lines (IC50 of ~35-150 nM). In human T cell assays, AHR antagonist 5 free base induces an activated T cell state. AHR antagonist 5 free base inhibits CYP1A1 and interleukin (IL)-22 gene expression and leads to an increase in pro-inflammatory cytokines, such as IL-2 and IL-9.
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体内实验AHR antagonist 5 free base (Compound A) has been evaluated in a series of pharmacological, single-dose and repeated-dose toxicological studies in rodent and non-rodent species including 28-day Good Laboratory Practice (GLP) studies in rat and monkeys. All changes are resolved or resolving after 2 weeks of dosing cessation, except for the testicular changes in rats.
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同义词——
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通路Others
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靶点Other Targets
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受体Aryl Hydrocarbon Receptor
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研究领域——
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适应症——
化学信息
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CAS Number2247950-42-9
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分子量441.5
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分子式C25H24FN7
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (226.50 mM; 超声助溶 )
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SMILESN(C=1N2C(=C(C(C)C)C=N2)N=C(N1)C=3C=C(F)C=NC3)[C@H]4CC=5C=6C(NC5CC4)=CC=CC6
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Marta Sanchez-Martin, et al. Ahr inhibitors and uses thereof. WO2021142180A1.
产品手册
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