KSC-34

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KSC-34 是蛋白质二硫键异构酶 A1 (PDIA1) 的共价修饰剂，是一种有效的 PDIA1a位点选择性抑制剂，IC50 为 3.5 μM。KSC-34 对 a′ 结构域的选择性为 30 倍。KSC-34 在复杂蛋白质组中对 PDIA 表现出选择性。KSC-34 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 μM. KSC-34 displays a 30-fold selectivity for a domain over a′ domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Others

Other Targets

Others

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2226201-97-2

429.95

C21H28ClN7O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (232.59 mM; 超声助溶 )

O=C(NCCNC1=NC(=NC(=N1)N(C)CCCCC=2C=CC=CC2)NCC#C)CCl

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(-20℃)

With Ice Pack

≥ 2 years