Disitamab vedotin ( —— )

产品货号. M35132 CAS No. 2136633-23-1

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产品名称

Disitamab vedotin
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Disitamab vedotin (RC48) 是一种抗体-活性分子偶联物 (ADC)，包含抗人表皮生长因子受体2 (HER2) 的单克隆抗体，该单克隆抗体通过可降解连接子结合到细胞毒性剂 MMAE。Disitamab vedotin 增强抗肿瘤免疫。
产品描述

Disitamab vedotin (RC48) is an antibody-drug conjugate (ADC) comprising a monoclonal antibody against human epidermal growth factor receptor 2 (HER2) conjugated via a cleavable linker to the cytotoxic agent Monomethyl auristatin E (MMAE). Disitamab vedotin enhances antitumor immunity.
体外实验

The antibody part was a humanized monoclonal antibody targeting HER2, the small molecule toxin was monomethyl auristatin E (MMAE), a synthetic antineoplastic agent. A protease cleavable linker covalently attached MMAE to the antibody.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Antibody-Drug Conjugates (ADCs) | EGFR
研究领域

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适应症

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1. Deeks ED. Disitamab Vedotin: First Approval. Drugs. 2021;81(16):1929-1935.?

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