RJW100 ( —— )

产品货号. M35057 CAS No. 1276664-20-0

RJW100 是一种有效的肝受体同源物 1 (LRH-1，NR5A2) 和类固醇生成因子-1 (SF-1，NR5A1) 激动剂，pEC50 分别为 6.6 和 7.5。RJW100 还可有效激活 miR-200c (miRNA-200c, microRNA-200c) 启动子。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥5567	有现货
10MG	￥7496	有现货
25MG	￥10881	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥5586	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

RJW100
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RJW100 是一种有效的肝受体同源物 1 (LRH-1，NR5A2) 和类固醇生成因子-1 (SF-1，NR5A1) 激动剂，pEC50 分别为 6.6 和 7.5。RJW100 还可有效激活 miR-200c (miRNA-200c, microRNA-200c) 启动子。
产品描述

RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter.
体外实验

RJW100 (compound 24-exo) treatment induces a significant dose-dependent increase in small/short heterodimer partner (SHP) transcripts beginning at 5 μM.RJW100 (compound 24-exo) clearly displaces the bound PIP2 phospholipid from SF-1 almost completely at 1 μM.Using hLRH-1 LBD alone that had not been complexed with any phospholipids, the result shows a clear dose-dependent shift in hLRH-1 LBD (ligand binding domain) native PAGE migration upon RJW100 (compound 24-exo; 0-100 μM) binding.RJW100 causes strong activation of the miR-200c promoter and exhibits strong ability to downregulate ZEB1 and ZEB2 proteins..RT-PCR Cell Line:HEK293 cells Concentration:1 μM, 5 μM, 10 μM Incubation Time:24 hours Result:Induced a significant dose-dependent increase in SHP transcripts beginning at 5 μM.
体内实验

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同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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化学信息

CAS Number

1276664-20-0
分子量

386.57
分子式

C28H34O
纯度

>98% (HPLC)
溶解度

——
SMILES

C(=C)([C@]12C(=C(CCCCCC)C[C@]1([C@H](O)CC2)[H])C3=CC=CC=C3)C4=CC=CC=C4
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Richard J Whitby, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14;54(7):2266-81.?

计算器

浓度计算器

摩尔计算器

分子量计算器

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