SQ609 ( —— )

产品货号. M35027 CAS No. 627052-25-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

SQ609
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

SQ609 是一种来自二哌啶库的先导化合物。SQ609 在 4μg/ml时抑制 90% 以上的细胞内细菌生长，并且对这些细胞有毒。SQ609 显示出强大的抗结核活性。
产品描述

SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity .
体外实验

In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells.
体内实验

SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days.Animal Model:TB susceptible mice (C3H/He)Dosage:10 mg/kg Administration:I.v.Result:Prevented weight loss in the Mtb-infected animals and prolonged the therapeutic effect following drug withdrawal for another 10-15 days.
同义词

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通路

GPCR/G Protein
靶点

Antibacterial
受体

Antibacterial
研究领域

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适应症

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1. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.?

计算器

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