Isoallolithocholic acid ( —— )

产品货号. M34853 CAS No. 2276-93-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Isoallolithocholic acid
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid)，Lithocholic acid (HY-10219) 的衍生物，是一种 T 细胞调节剂。Isoallolithocholic acid 增强调节性 T 细胞 (Tregs) 的分化。
产品描述

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid), a derivative of Lithocholic acid (HY-10219), is a T cell regulator. Isoallolithocholic acid enhances regulatory T cells (Tregs) differentiation.
体外实验

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体内实验

Animal Model:Segmented filamentous bacteria (SFB)-colonized Jax-B6 miceDosage:0.03% (w/w) Administration:In diet, 7 days Result:Was insufficient to enhance Treg percentages both at steady state and following anti-CD3 treatment alone. Significantly enhanced the Treg population in mice treated with anti-CD3 compared to control diet in combination with 0.3% (w/w) 3-oxolithocholic acid (3-oxoLCA). Reduced the number of CD45.1+ T effector cells.
同义词

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通路

Others
靶点

Other Targets
受体

Others
研究领域

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适应症

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CAS Number

2276-93-9
分子量

376.57
分子式

C24H40O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 83.33 mg/mL (221.29 mM; 超声助溶 (<60°C); H2O 中的溶解度 : < 0.1 mg/mL (insoluble)
SMILES

[H][C@@]12CC[C@H]([C@H](C)CCC(O)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@@H](O)CC[C@]12C
化学全称

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1. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.?

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