OPC 8490 free base
CAS No. 106752-32-3
OPC 8490 free base ( —— )
产品货号. M34674 CAS No. 106752-32-3
OPC 8490 free base is a novel positive inotropic vasodilator and a cardiotonic agent that increases Ca currents in a dose-dependent and reversible manner and can be used to study cardiovascular diseases.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ¥3088 | 有现货 |
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| 10MG | ¥4513 | 有现货 |
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| 25MG | ¥6956 | 有现货 |
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| 50MG | ¥9179 | 有现货 |
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| 100MG | ¥12240 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称OPC 8490 free base
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述OPC 8490 free base is a novel positive inotropic vasodilator and a cardiotonic agent that increases Ca currents in a dose-dependent and reversible manner and can be used to study cardiovascular diseases.
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产品描述OPC 8490 free base is a novel positive inotropic vasodilator and a cardiotonic agent that increases Ca currents in a dose-dependent and reversible manner and can be used to study cardiovascular diseases.
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体外实验——
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体内实验——
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同义词——
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通路GPCR/G Protein
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靶点Calcium Channel
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受体Calcium Channel
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研究领域——
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适应症——
化学信息
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CAS Number106752-32-3
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分子量405.49
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分子式C24H27N3O3
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纯度>98% (HPLC)
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溶解度——
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SMILESO=C(C1=CC=C2NC(=O)CCC2=C1)N3CCN(CC3)CCCC(=O)C=4C=CC=CC4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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(±)-Liquiritigenin
(±)-Liquiritigenin ((±)-4',7-Dihydroxyflavanone) 是从 Angelica keiskei 中分离得到的,Angelica keiskei 是伞形科的一种耐寒多年生草本植物。(±)-Liquiritigenin 可以促进细胞增殖,具有细胞保护活性,降低细胞毒性,同时也具有抗氧化应激作用。
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GSK205
GSK205 是一种高效的,选择性的 TRPV4 拮抗剂,IC50 值为 4.19 μM,可抑制 TRPV4 介导的 Ca2+ 内流。
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Oxodipine
Oxodipine, a dihydropyridine-type calcium antagonist, inhibited KCl-induced aortic contraction in rabbits and reduced cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduced L-type Ca currents (I) with an IC of 0.24 μM, and against T-type Ca currents (I) with an IC of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs.
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