(Rac)-Modipafant

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

(Rac)-Modipafant (UK-74505) 是一种口服的、选择性的、长效的不可逆血小板活化因子受体 (PAFR) 受体拮抗剂。(Rac)-Modipafant 预防严重登革热感染。

(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.

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(Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.Animal Model:8- to 10-week-old BALB/c mice (DEN-2 strain infected) Dosage:10 mg/kg Administration:P.o.; twice a day (started on days 0, 3, 5, or 7) until day 10 Result:Decreased by approximately 50% the lethality associated with DEN-2 infection.Animal Model:Male BALB/C (8- to 10- week-old) wild-type mice Dosage:5, 10 and 20 mg/kg Administration:P.o.Result:Dose-dependently inhibited the Zymosan -induced articular hyperalgesia.

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Others

Other Targets

PAFR

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122956-68-7

605.09

C34H29ClN6O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (82.63 mM; 超声助溶 )

O=C(OCC)C1=C(NC(=C(C(=O)NC2=NC=CC=C2)C1C=3C=CC=CC3Cl)C)C=4C=CC(=CC4)N5C(=NC=6C=NC=CC65)C

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(-20℃)

With Ice Pack

≥ 2 years