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Roxindole
CAS No. 112192-04-8
Roxindole ( —— )
产品货号. M34133 CAS No. 112192-04-8
Roxindole (EMD 49980)，一种吲哚烷基哌啶，是多巴胺自身受体 (dopamine autoreceptors) 的有效激动剂，在低纳摩尔范围内与 D2 样亚型具有亲和力。Roxindole 可用于研究阳性和阴性精神分裂症症状。Roxindole 是 5-HT1A 激动剂和 5-羟色胺 (5-HT) 的摄取的抑制剂。具有抗精神病药和抗抑郁药活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥4674 | 有现货 |
|
| 10MG | ￥6774 | 有现货 |
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| 25MG | ￥9858 | 有现货 |
|
| 50MG | ￥13206 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Roxindole
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Roxindole (EMD 49980)，一种吲哚烷基哌啶，是多巴胺自身受体 (dopamine autoreceptors) 的有效激动剂，在低纳摩尔范围内与 D2 样亚型具有亲和力。Roxindole 可用于研究阳性和阴性精神分裂症症状。Roxindole 是 5-HT1A 激动剂和 5-羟色胺 (5-HT) 的摄取的抑制剂。具有抗精神病药和抗抑郁药活性。
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产品描述Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor. Antipsychotic and antidepressant activities.
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体外实验——
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体内实验Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.).Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g).
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor | Dopamine Receptor
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研究领域——
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适应症——
化学信息
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CAS Number112192-04-8
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分子量346.47
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分子式C23H26N2O
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纯度>98% (HPLC)
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溶解度——
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SMILESOC=1C=CC=2NC=C(C2C1)CCCCN3CC=C(C=4C=CC=CC4)CC3
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Bartoszyk GD, Harting J, Minck KO. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48.?
产品手册
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