Mepacrine ( —— )

产品货号. M34002 CAS No. 83-89-6

COA

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HNMR

HPLC

MSDS

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产品名称

Mepacrine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Quinacrine (Acriquine) 是一种抗疟疾和抗癌剂。Quinacrine 还抑制人醛氧化酶 (aldehyde oxidase) (IC50: 3.3 μM)。Quinacrine 对核酸具有亲和力，并对固定细胞中的 DNA 和 RNA 染色 (Ex/Em: 436/525 nm)。
产品描述

Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm).
体外实验

Cell Viability Assay Cell Line:SGC-7901 cell Concentration:0, 5, 10, 15, 20 μM Incubation Time:24 h Result:Inhibited cell growth with an IC50 value of 16.18 μM.
体内实验

Animal Model:Acute kidney injury rat model Dosage:3-30 mg/kg Administration:i.p.Result:Attenuated glycerol induced structural and functional changes in kidney.
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研究领域

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适应症

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1. Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46(17):3563-4. ?

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